Hello,
Yes it is, here is a paper in which set up Chi.Bio reactors with an Opentrons and various other pieces of kit:
https://www.nature.com/articles/s41467-022-31033-9
Also, all the software is already written in Python so if you are familiar with some SSH /webserver skills etc you can easily set it up to be controlled from your own external software package as the authors above have done. Or, you can easily enough implement different communications protocols (e.g. send HTTP requests to the Chi.Bio server that runs on the control computer to get it to do different things).
Harrison